Microplastic pollution has emerged as a critical environmental concern threatening marine ecosystems and food security along the West African coast. This comprehensive study assessed microplastic contamination levels in commercially important edible marine fish species collected from six countries along the West African coastline. Fish samples (n=480) representing 12 species were collected from coastal waters of Morocco, Senegal, Guinea-Bissau, Sierra Leone, Ghana, and Nigeria during 2023-2024. Microplastic particles were extracted using enzymatic digestion and density separation techniques, followed by microscopic identification and polymer characterization using FTIR spectroscopy. Results revealed widespread microplastic contamination across all sampled locations, with mean particle concentrations ranging from 2.3 ± 1.2 to 8.7 ± 3.4 particles per gram of tissue. Polyethylene (PE) and polypropylene (PP) were the most abundant polymer types, accounting for 68% of identified particles. Pelagic species showed significantly higher contamination levels compared to demersal species (p<0.001). The findings indicate substantial microplastic exposure risks for coastal populations dependent on marine fish protein, highlighting the urgent need for comprehensive plastic waste management strategies and continued monitoring programs along the West African coast.